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While metabolic changes (like improved sleep and energy) can often be felt within the first few weeks, significant changes in body compositionsuch as muscle gain and fat losstypically require 3 to 6 months of consistent therapy alongside proper nutrition

155,156 GIPR activation also promotes insulin release, especially after meals, helping to improve glucose utilization

Example: Someone stable on levothyroxine for years, TSH around 2, starts an over-the-counter supplement with L-carnitine and notices increasing tiredness and a later TSH of 5

Los pacientes perdieron, en promedio, 2,5 kilos durante ese perodo, lo que por supuesto no los dej satisfechos

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