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FA metabolic dysfunction is a contributing factor to LVR, and long-term LVR creates a vicious cycle that exacerbates the development of heart failure and leads to a poor prognosis in other cardiovascular diseases (Lionetti et al., 2011
(2021) 143:e984e1010
For instance, the Taiwanese database in Kornelius 2024 included 324,506 subjects, the Nordic (Sweden and Denmark) active-comparator new-user study enrolled 298,553 patients, and the UK study by Shapiro 2025 included 270,110 patients with type 2 diabetes
Potential long-term effects could include joint pain and increased risk of diabetes due to altered glucose metabolism
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