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The primary driver is the need to preserve lean mass and dietary quality while GLP-1 medicines reduce appetite and change meal tolerance
The hypothesis is biologically plausible and supported by ingredient-level evidence
18 Most of these studies do not report HF diagnostic criteria or mention HF therapy, and only one trial reported on left ventricular ejection fraction (LVEF) at baseline
Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss
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