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A synthetic form of this peptide, called Exenatide, was the first incretin analog approved by the US FDA to treat diabetes
Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)
The effects are indirect they come from how the medication changes your mouths environment, not from the drug touching your teeth
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Cancer Res 54 : 22182222 Resnicoff M, Tjuvajev J, Rotman HL, Abraham D, Curtis M, Aiken R, Baserga R (1996) Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA
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