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The most frequently reported adverse effects of tirzepatide in pivotal clinical trials were predominantly gastrointestinal in nature, consistent with the drug class mechanism of delayed gastric emptying
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To annotate the non-neuronal atlas, an atlas consisting of 20,000 cells from the hippocampus profiled with the 10x Genomics platform 35 was used
Both approaches significantly lowered HbA1c levels (weighted mean difference [WMD] 0.75%, 95% CI 0.97 to 0.53) but increased hypoglycemic risk [risk ratio (RR) 7.59, 95% CI 3.3517.17] compared to the unchanged GLP-1RA
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