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This sustained contraction reduces blood flow and irritates nerve endings
Since the astrocytic K + uptake also depends on glycogenolysis-activated signaling (to facilitate Na + access to the Na + ,K + -ATPases Na + -sensitive site), it must also be absent in neonatal brain
From an implementation standpoint, the standardized liquid formulation enables rapid local absorption with minimal systemic exposure and ensures uniform mucosal coverage, consistent dosing, and prolonged mucosal contact, features likely to reduce the formulation heterogeneity that has hampered prior topical studies and to enhance adherence 21
doi: 10.3390/cells11233923 117 LeeMBanJJKimKYJeonGSImWSungJJet al
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