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MT-1s MC1R-preferential activity makes it the primary research tool for studying MC1R biology in pigmentation, photoprotection, and skin immunology without the confounding central melanocortin receptor activation that limits the interpretability of studies using less selective melanocortin agonists

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Although the analysis did not focus specifically on Melanotan 1, MC1R and related melanocortin receptors were discussed as potential modulators of pigment linked cellular responses beyond the epidermal layer