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Meanwhile, in the latest animal studies, some researchers found that exendin-4 can reduce levels of serum VLDL cholesterol and low-density lipoprotein cholesterol (LDL-C) by reducing liver sterol regulatory element binding protein 2 (SREBP2) level and cholesterol absorption [75]

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This study established the connection between enlarged naevi and melanoma risk, which led to the concept of dysplastic naevi as precursor lesions to melanoma

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