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9 The STEP-HFpEF DM randomised controlled trial enrolled 616 patients with obesity (BMI 30 kg/m 2 ) and both HFpEF (LVEF 40%) and T2D
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Environmental factors such as bedroom temperature, bedding materials, and sleepwear should also be evaluated before pursuing extensive medical workup

However, maintaining consistent dosing helps support the best long-term results

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