I now SI every 2 weeks although I still have some mild neuro symptoms (unsure whether I should be doing this more frequently)
The study looked at the change from baseline in LFC as assessed by MRI-proton density fat fraction (MRI-PDFF) at week 52
Notably, compensatory crosstalk may limit monotherapy efficacymelanoma cells escaping ferroptosis via FSP1 upregulation may become more dependent on necroptosis suppression, and vice versaunderscoring the rationale for co-targeting multiple pathways to avoid adaptive resistance ( 5 Synergistic therapeutic strategies targeting RCD pathways and immune checkpoint inhibitors Regulated cell death (RCD) pathways, including ferroptosis, pyroptosis, and necroptosis, have emerged as crucial modulators of antitumor immunity, serving as a bridge between tumor cell elimination and immune response activation (123)
It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain
Dosage: Never exceed the intended dose to avoid side effects