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Sci Transl Med 11(523) Wang S et al (2020) An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics
Its route is shaped by NHS evidence expectations and private virtual-care services that must fit defined clinical pathways
Recent data from the ATTAIN-MAINTAIN trial showed that patients transitioning to orforglipron after injectable GLP-1 therapy maintained their weight loss with minimal regain (approximately 0.9 kg after semaglutide transition), suggesting that oral maintenance strategies could minimize the lean mass depletion seen with prolonged high-dose injectable therapy
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