Semaglutide slows gastric emptyingthe rate food leaves your stomachso heavy, fatty meals sit longer and trigger more pronounced side effects
Unlike semaglutide, which targets only GLP-1 receptors, tirzepatide is a dual agonist it activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously
Choosing between these two depends on your current wellness priorities
Tirzepatides common side effects include: Nausea Vomiting Diarrhea Stomach pain Decreased appetite Risk of low blood sugar Constipation Serious side effects of tirzepatide can include pancreatitis (inflammation of the pancreas), gallbladder problems, kidney problems, and severe allergic reactions
The authors also emphasized that the wider use of these drugs should consider social and commercial determinants of health, including access, affordability and insurance coverage, to avoid deepening existing health inequities among people living with obesity