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However, it is essential to note that sustained elevation in plasma glucose concentrations due to reduced pancreatic insulin release from chronic melatonin treatment, especially when extending beyond the sleeping period [140], may compromise melatonins potential to ameliorate AD pathology [141, 142]
Slower escalation reduces the risk of severe nausea and dehydration, which can be more dangerous in older adults with reduced physiological reserves
Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells [low GLP-1R expression in human C-cells]
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