Finding a safe, reliable source for semaglutide matters, but what happens after you start does, too
But a small number of people may experience eye-related side effects, especially if they already have certain eye conditions

References Biomolecules (MDPI) Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports Dopinglinkki (FINCIS Anti-Doping Authority) Insulin-like growth factor 1 (IGF-1) and long chain IGF (LR3IGF-1): Medical information and safety overview Mayo Clinic / IBM Micromedex Mecasermin (Subcutaneous route): Proper Use and Handling guidance on IGF-1 administration timing with meals Cell Sciences (Research Reagents) Recombinant Human LR3 IGF-1: Product technical datasheet including storage and stability specifications Centers for Disease Control and Prevention (CDC) Preventing Unsafe Injection Practices: One Needle, One Syringe, Only One Time Drugs.com Increlex (mecasermin) Dosage Guide: Clinical dosing and hypoglycemia management for IGF-1 therapy AnabolicMinds Community Research Forum Storage and cycle considerations for IGF-1 LR3: Practical protocol discussions Immunize.org (Immunization Action Coalition) How to Administer Subcutaneous Vaccine Injections: Site selection and rotation guidance ReliaTech GmbH Human IGF-1 LR3 Protein Technical Specifications: Reconstitution and storage protocols Mayo Clinic Mecasermin (subcutaneous route): Side effects and proper handling solution inspection guidelines Frontiers in Bioengineering & Biotechnology Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury Drug Testing and Analysis (PubMed) Detection of LongR3-IGF-I, Des(1-3)-IGF-I, and R3-IGF-I using immunopurification and high resolution mass spectrometry for antidoping purposes Centers for Disease Control and Prevention (CDC) Chapter 6: Vaccine Administration (Pink Book): Comprehensive subcutaneous injection technique guidance NCBI Bookshelf 5.6 Administering Subcutaneous Medications: Clinical best practices for subcutaneous injection technique Related research, protocols, and guides Explore the available research context, protocol variants or comparisons, and practical guides

It was also noted that the promoter region of the GSTA3 gene contains three putative binding sites for steroidogenic factor 1 (SF-1), which serves as a master regulator of endocrine functions
The incidence and severity of GI side effects would almost certainly be dramatically higher, leading to poor protocol adherence and a high dropout rate