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doi: 10.3389/fmolb.2025.1727385 Palacios S
When semaglutide suppresses appetite and reduces caloric intake by 20 to 40%, the body enters a state of energy deficit
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Metabolic actions of GLP- 1/ GCG receptor co-agonists on key organs [see Figure 1] Recently developed unimolecular GLP-1/GCG receptor co-agonists have elicited robust glycemic control and promote sustained weight loss in animals [18, 19, 20] and have shown superior preclinical efficacy compared to currently prescribed monotherapies in the treatment of obesity
Additionally, two patients started growth hormone treatment closely with the initiation of semaglutide, complicating the interpretation of the respective contributions of weight loss and growth hormone treatment on improvements in physical performance and fitness
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