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GIP Receptor Limb GIPR engagement is the distinguishing feature separating dual agonists such as tirzepatide from single GLP-1R agonists
It is known for its potent anti-inflammatory properties and its ability to promote cell migration to sites of injury
Phytomedicine 2015
it is known that this signaling pathway is closely associated with articular cartilage surface destruction during the occurrence and development of RA, which may be related to its regulation of chondrocyte ferroptosis and promotion of inflammatory factor expression, as supported by RNA sequencing, molecular biology experiments, and both in vivo/in vitro experiments
The qPCR assay was performed using 2 iTaq Universal SYBR Green Supermix (catalog number: 1725121, Bio-Rad Laboratories, Hercules, CA) according to the Bio-Rad manufacturers instructions
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