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Start at 600 mg/day and increase to 1,200 mg if needed
52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
How long does it take to start treatment
This is not disproportionate
Usually, the next step is to use mass spectrometry to identify those interacting proteins (Kassa et al, 2023)
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