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doi.org/10.3390/ijms19071987 Hureau, C., et al

For example, the deletion of the core clock gene Bmal1 in the mouse brain led to astrocyte activation - an established marker of brain and neuronal injury - as well as synaptic degeneration [179]

Collectively, these findings suggest that behavioral recovery in ASD models involves mechanisms that are more complex than the mere normalization of oxidative stress markers, requiring the integration of multiple neural circuits and pathophysiological processes

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