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This is because oral intake of glutathione reduces the potential side effects associated with intravenous administration but might have the disadvantage of lesser bioavailability
Accumulation of -synuclein causes stress in the endoplasmic reticulum and affects protein folding, leading to the unfolded protein response [9]
This indicates that a substantial part of the GSH pool is in an oxidized state in the gastrointestinal lumen, which is mainly related to the fact that intracellular levels of GSH and other components of the redox environment are more heavily regulated by the cell as compared to the redox environment of the extracellular space (48)
For those who prefer the oral route, liposomal glutathione is the modern gold standard, as it uses lipid spheres to protect the molecule during digestion
doi: 10.3390/jof8020204 133 ReganJ.DeJarnetteC.ReitlerP.GihazS.SrivastavaA.GeW.et al
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