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Encapsulating rapamycin within poly (lactic-co-glycolic acid) (PLGA) nanoparticles for targeted delivery not only enhances rapamycins water solubility and bioavailability but also significantly reduces the expression of drug-resistance-related genes, such as mTOR and Bcl-2, in bladder cancer cells, thereby increasing apoptosis rates and drug sensitivity (48)

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Bioavailabilit y: Oral B12 supplements require intrinsic factor, a protein in the stomach, for absorption