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Most people notice appetite suppression within the first week of their initial 2.5mg dose

By enhancing insulin secretion and reducing appetite, it helps patients achieve significant weight loss while also improving overall metabolic health

1,79 Insulin dose reduction: Improvement in insulin sensitivity, leading to rapid and substantial reductions in total daily insulin requirements, often by 2030% within the first 23 months

Consultation Your healthcare provider will: Review your medical history Assess how you responded to semaglutide Evaluate recent weight and metabolic trends Determine whether switching aligns with your health goals This is the most important step, as individualized guidance helps ensure safe dosing

Heres what scientists think is going on