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The Limitations of Traditional Melasma Treatments Conventional approaches to treating melasma have included: Topical agents (hydroquinone, retinoids, corticosteroids) Chemical peels Conventional laser therapies Oral medications Lifestyle modifications Sun protection measures While these methods can offer some improvement, they often fall short of delivering comprehensive, long-lasting results

The SLCO (former SLC21) superfamily of transporters

If that's the reason

It provides an alternative for patients absolutely averse to injections