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Insulin resistance can cause hyperinsulinemia (high insulin) and affect hormones that regulate appetite, both of which could drive excess calorie intake and lead to weight gain or obesity
23, 24 We have therefore evaluated GLP1R in human thyroid and pancreas tissues using an extensively validated GLP1R monoclonal antibody 24 that we used for immunohistochemistry and western blots and that we compared with results of GLP1R autoradiography in the same tissues
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The most common side effects are nausea, vomiting, diarrhea, and abdominal discomfort, which are usually mild and subside over time
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