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Moreover, the activation of protein kinase R-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 subunit (eIF2a)-activation transcription factor 4 (ATF4) signaling pathway causes cellular iron overload and enhanced sensitivity to ferroptosis by upregulating the ATF3-mediated expression of NCOA4 and TFR1, which are related to the impaired iron storage caused by ferritinophagy induction and the increased iron uptake caused by the promotion of iron importation, respectively (42)
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Kothawade SM, Buttar HS, Tuli HS, Kaur G (2023) Therapeutic potential of flavonoids in the management of obesity-induced Alzheimers disease: an overview of preclinical and clinical studies
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Shalitin, S
