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Hematologic and myeloproliferative disorders Several blood disorders drive B12 up by increasing the production of its carrier proteins

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Essas anormalidades metablicas podem causar alteraes clnicas importantes como: fraqueza muscular e miopatia, perda de protena corporal e caquexia, resistncia insulnica e intolerncia glicose, anormalidades do metabolismo lipdico, anemia refratria ao tratamento com eritropoetina, cardiomiopatia e sintomas intradialticos (cibras, hipotenso e arritmia cardaca) 24,27

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