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10.1126/science.2402639 21 CohenT

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LY, XC, YC,YL, LY, YX, CM, and YZ collected the literature, wrote the manuscript, and prepared figures

As the bodys most abundant intracellular antioxidant, glutathione serves as a crucial defense system against oxidative stress and plays multiple roles in maintaining cellular health: Neutralizes free radicals: Directly scavenges reactive oxygen species (ROS) Regenerates other antioxidants: Recycles vitamins C and E Detoxification: Conjugates with toxins for elimination Immune function: Enhances activity of immune cells Cell signaling: Regulates cellular proliferation and apoptosis Mitochondrial protection: Maintains mitochondrial integrity Glutathione in Metabolic Health While primarily known for its antioxidant properties, glutathione plays significant roles in metabolic health that are particularly relevant to weight management practices: Insulin sensitivity: Helps maintain normal insulin signaling pathways Adipocyte function: Influences fat cell metabolism and inflammation Hepatic health: Protects against fatty liver disease Mitochondrial efficiency: Promotes optimal energy production Inflammatory regulation: Modulates chronic inflammation associated with obesity Research has shown that obesity and metabolic syndrome are associated with depleted glutathione levels, creating a state of increased oxidative stress that can exacerbate metabolic dysfunction

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