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More recently, mGPDHs protective function was validated in vivo: in a mouse model of sepsis-induced acute lung injury, mGPDH knockdown exacerbated lung injury, vascular leakage, inflammation and oxidative damage, accompanied by elevated ferroptotic markers 100
This neutralization is achieved through a process called glutathione conjugation, catalyzed by a superfamily of enzymes known as Glutathione S-Transferases (GSTs)
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