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Co-agonism showed, on murine models, the capability to improve insulin secretion and sensitivity in a weight-dependent and weight-independent manner, probably through its action on nutrient metabolism (49, 50), preventing their accumulation and thus making these organs actively involved in metabolism with an improvement in insulin sensitivity and WL, yielding long-lasting effects
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First, not all people included in the study had evidence in their medical records for T2D or overweight/obesity, although this may indicate off-label use and provide some visibility into this group
The study concluded that GHK-Cu provides a safer alternative for copper delivery
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