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Glutathione has long been identified as an essential molecule required by the body because of its potency as an antioxidant

Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: an elephant in the room

Their acidic lumen and relatively fragile membrane render them particularly susceptible to nanomaterial accumulation, which can induce localized reactive oxygen species (ROS) generation, ionic imbalance, or osmotic stress, ultimately leading to lysosomal membrane permeabilization (LMP)

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