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49 Further evaluation on a double-blind, randomized phase 1 clinical trial in 98 patients with T2DM on current management with metformin revealed that Danuglipron was generally well tolerated and associated with minimal side effects such as nausea, dyspepsia, and vomiting comparable with the ones observed with the use of injectable GLP-1RA

Maintaining muscle while losing fat is one of the critical challenges in any weight loss protocol, and semaglutide performs better than caloric restriction alone on this measure

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As the disease progresses, macrophages can shift toward the M2 phenotype, contributing to tissue repair and fibrosis

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