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Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity
Dulaglutide 0.6 mg/kg group (DUL 0.6 mg/kg): received 0.6 mg/kg of DUL by (ip) twice weekly for 14 days and single dose (ip) of DOX (20 mg/kg) on the 13th day of study
These compounds address underlying pathology including collagen disorganization, persistent inflammation, and impaired blood supply
To this end, DPP-4 knockout mice also showed similar findings, indicating that DPP-4 inhibition is an effective mechanism for treating T2DM [45]
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