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Larazotides mechanism involves binding to receptors on gut epithelial cells and preventing the signaling cascade that leads to tight junction disassembly
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Chronic heavy alcohol consumption can lead to alcoholic cardiomyopathy, characterized by left ventricular dilation, reduced myocardial contractility, and myocardial fibrosis, ultimately resulting in heart failure and arrhythmias [53]
Long-term safety data for peptides used specifically for GERD is limited because most trials are short-duration pilot studies
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