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Market Context The partnership comes ahead of the expected patent expiry of the innovator molecule around March 21, which is anticipated to open the Indian market to broader competition among domestic drugmakers
A 2003 double-blind placebo-controlled trial by Humbert and colleagues in Experimental Dermatology applied 5% topical ascorbic acid cream versus vehicle to the low-neck and arms of healthy women with photoaged skin for 6 months, with assessments at baseline, 3 months, and 6 months, and found that active treatment improved skin relief and silicone-replica topography and produced favorable changes on end-of-study immunohistochemistry and electron microscopy of dermal biopsies biopsy-level evidence of structural remodeling, not merely surface appearance
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doi: 10.1002/clt2.12283, 119
