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Nonetheless, the distinct regional and quantitative differences in fat loss between the sexes highlight the need to consider sex-specific effects in obesity treatment [53]

Advances in therapy, 38(6), 28212839

doi:10.1016/S0140-6736(19)31271-1 30

It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case