While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]
In particular, the upregulation of IL6, IL1, and Stat3, along with alterations in immune cell populations such as MDSCs and regulatory T cells, and inflammasome suggest plausible mechanistic links to BC pathogenesis 137
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