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Rodents have a substantially higher density of GLP-1 receptors on thyroid C-cells compared to humans, making them more susceptible to C-cell proliferation

Results revealed significant reductions in tibial nerve cross-sectional area (CSA), an indicator of nerve swelling, with 86% of participants exhibiting reduced CSA and 32% achieving normal nerve morphology [89]

It is hoped that ongoing trials like SUMMIT, which is investigating tirzepatide in participants with HFpEF and obesity, will provide more evidence on incretin-based medications in HFpEF

Cecon E, Chen M, Marola M, Fernandes PA, Jockers R, Markus RP

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