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EGF treatment increased H 2 O 2 production, which activated the AKT/p70S6K1 pathway to transcriptionally enhance VEGF expression

A single report from the Bakr group describes the phase transfer of GSH-capped silver nanoclusters from water to dichloromethane (good solvent for PLGA preparation) using tetraphenylphosphonium bromide 32

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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

All statistical analyses were performed by using SPSS version 16.0 for Windows (SPSS, inc., Chicago, IL, USA)