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The half-life of semaglutide was approximately 1 week in all groups
Moreover, vitamin D suppresses pro-inflammatory cytokines including TNF- and IL-6, both implicated in obesity-associated insulin resistance (25) These mechanisms are biologically concordant with the established metabolic effects of semaglutide, which include enhancing insulin secretion, reducing glucagon levels, and promoting satiety through central hypothalamic signaling (26)
In post-bariatric patients who may already experience gastrointestinal sensitivity, gradual dose titration is particularly important
CSE is mainly expressed in Sertoli cells and immature spermatogonia, while CBS is mainly distributed in Leydig cells, Sertoli cells, and germ cells (66)