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These patterns act as ligands for pattern recognition receptors (PRRs) expressed on the microglial surface, most notably Toll-like receptors 2 and 4 (TLR2 and TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) [54]

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Importantly, mTOR inhibition (e.g., via rapamycin) helps maintain astrocytes in a protective state and reduces neuronal lipid peroxidation damage (Zhang et al., 2025c)

Abstract Acute valproic acid intoxication is an increasing problem, accounting for more than 5000 calls to the American Association of Poison Control Centers in 2000

Vitamin supplements help, but much of it is lost through digestion