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In the Phase 3 REDEFINE 1 trial, cagrilintide monotherapy achieved 11.8% average weight loss over 68 weekscomparable to semaglutide but with a notably lower incidence of nausea and vomiting, making it a potential option for patients who dont tolerate GLP-1 medications well
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While they share some overlapping areas of investigation, they differ significantly in structure, origin, and proposed mechanisms
Stockburger et al., 2015
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