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In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH

doi: 10.1016/j.patbio.2009.09.014 11

Its 3-letter sequence, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Asn-His (31 residues as tabulated with N-terminal modification), features a single methionine that analysts should note as a potential oxidation site during method development, alongside multiple basic residues (Arg, Lys, His) that dominate its charge state envelope in positive-mode ESI-MS

A follow-up biomarker panel at the end of a 3 to 4-month cycle gives objective data that the protocol is moving the right numbers, which is more informative than any subjective assessment

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