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The liver tissue of the control group displayed distinct polyhedral-shaped large hepatocytes with well-preserved cytoplasm and rounded euchromatic nucleus with prominent nuclei, forming hepatic cord-like structures (Fig
Similar cysteine levels at 3568 M were observed in SCD mouse plasma (Supplementary Fig
The existing body of evidence indicates that metformin, when administered at therapeutic doses, maintains its plasma concentration within the micromolar range
However, individual suitability should be assessed through a pre-treatment consultation to help identify any potential risks or contraindications
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