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I explained this is not a character flaw it is chemistry and hormones: Aromatase in adipose converts testosterone to estrogen reduced testosterone, increased estrogen fatigue, mood changes, lower muscle mass, more abdominal fat, impaired sperm and erectile function Cortisol and insulin under chronic stress and poor sleep elevate appetite (comfort foods), drive fat storage (especially visceral), and magnify insulin resistance (Bornstein et al., 2018) Ghrelin-Leptin-GLP-1 axis : Ghrelin increases hunger Leptin resistance blunts satiety signals Impaired GLP-1 signaling reduces fullness Chronic inflammation from adipokines fuels metabolic dysfunction His struggle is biochemical, not moral

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Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance

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