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PMCID: PMC7988425
Within the CNT and cortical collecting ducts AQP2, present in principal cells, is the primary aquaporin responsible for vasopressin-mediated regulation of fluid balance within the kidneys
Understanding that continued medication use will likely be necessary helps frame expectations appropriately
Blood pressure, triglycerides, liver fat, and insulin sensitivity all improved across multiple studies
This recommendation is particularly important for patients experiencing significant glucose reduction with metformin initiation
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