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[1] [2] The physiologic role of GLP-1 includes stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

A study by Maratou et al

They might not be as strong as medical treatments

Tirzepatide controls blood sugar by stimulating insulin release, lowering glucagon levels and regulating appetite and energy metabolism for weight management

Pigment storage is a consequence of colonic epithelial cells apoptosis, in which the apoptotic cells are swallowed by macrophages, which migrate in the lamina propria and the conversion into lipofuscin pigment occurs by lysosomal enzymes (19)