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The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
Tirzepatide copies two hormones: GLP-1 and GIP
10.1002/iub.1616 11 GioulekaS.TsakiridisI.ArsenakiE.KalogiannidisI.MamopoulosA.PapanikolaouE.et al (2023)
Clinical studies have demonstrated the effectiveness of Semaglutide for weight loss
10.1016/j.atherosclerosis.2013.03.004 129
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