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In this study, excitation-emission spectra of the dye 2-(4-dimethylamino)-3-hydroxyflavone (DMAF) were recorded upon interaction with four representative bacteria: Gram-negative Staphylococcus aureus and Bacillus subtilis and Gram-positive Klebsiella pneumoniae and Escherichia coli
Notably, PGRMC1 also binds other cytochrome P450 enzymes, such as cytochrome P450 family 3 subfamily A member 4 (CYP3A4), suggesting that individual variability in PGRMC1 function may influence broader drug metabolism pathways [49]
They explain tirzepatide in isolation, or they mention B12 as a footnote
Individual variation in metabolic response is significant
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