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however, in the case of injury or disease, loss of NMNAT activity leads to NAD + depletion and NMN accumulation, which in turn activates SARM1 53,54,289

GHK-Cu : Demonstrates wound healing and regenerative potential, with both topical and injectable uses of interest to prescribers Letter on peptides ignores lack of data and peptide risks I believe the claims are mostly aspirational

That decline correlates with reduced skin repair capacity, but the correlation does not prove that topical supplementation reverses the deficit