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Standard recommendations use 2mg administered 3-7 times weekly

Obesity contributes to up to half of new diabetes cases annually in the United States

Dysesthesia, or unusual skin sensations such as tingling or altered sensitivity, has been reported in newer retatrutide clinical trial data

This dynamic produced a largely unregulated online marketplace where telehealth companies and other sellers mass-produced and widely promoted compounded GLP-1 drugs containing a different source of the active pharmaceutical ingredient (what drugs are made from), meaning the compounded versions were not the same and according to the FDA, could contain incorrect doses, too much or too little of the active ingredient, and possibly contaminants and bacteria

Pharmacol Rev 2003, 55:167-194