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Statistical analysis All analyses were conducted using the RStudio version 1.4.17.17 software by the packages meta and metafor. We used the method suggested by the Cochrane handbook to calculate the sample size and event [19]

It can be challenging to navigate these conversations without getting defensive or feeling like I need to explain myself

doi: 10.1016/j.cell.2012.02.010

This raises questions about cost-effectiveness and access, but if priced reasonably or if generics eventually become available, we may see a broad shift where anti-obesity pharmacotherapy (especially GLP-1/GIP-based) is as commonplace as antihypertensive or lipid-lowering therapy

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